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Nirogacestat (dihydrobromide) [CAS 1962925-29-6]

Nirogacestat (dihydrobromide) [CAS 1962925-29-6]

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QM-0075696-01

£187.29 GBP
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Product Details

  • Description

    Nirogacestat dihydrobromide (PF-3084014 dihydrobromide) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by Nirogacestat dihydrobromide while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers[1].

  • CAS Number

    [1962925-29-6]

  • Molecular Formula

    C27H43Br2F2N5O

  • Molecular Weight

    651.47

  • Smiles

    FC1=C2C(CC[C@H](N[C@@H](CCC)C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)=O)C2)=CC(F)=C1.Br.Br

  • Target

    Apoptosis; γ-secretase

  • Purity

    99.9

  • Solubility

    DMSO : 80 mg/mL (ultrasonic)

  • Storage Conditions

    4°C (Powder, sealed storage, away from moisture)

  • Shipping Conditions

    Room Temperature
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Variant Variant total Quantity Price Variant total
5 mgQM-0075696-01
5 mgQM-0075696-01
£187.29/ea		 £0.00
£187.29/ea £0.00
10 mM - 1 mLQM-0075696-02
10 mM - 1 mLQM-0075696-02
£245.62/ea		 £0.00
£245.62/ea £0.00
10 mgQM-0075696-03
10 mgQM-0075696-03
£256.55/ea		 £0.00
£256.55/ea £0.00
50 mgQM-0075696-04
50 mgQM-0075696-04
£878.63/ea		 £0.00
£878.63/ea £0.00
100 mgQM-0075696-05
100 mgQM-0075696-05
£1,430.24/ea		 £0.00
£1,430.24/ea £0.00
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Nirogacestat (dihydrobromide) [CAS 1962925-29-6]

Nirogacestat (dihydrobromide) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.