Nirogacestat (Standard) [CAS 1290543-63-3]
Nirogacestat (Standard) [CAS 1290543-63-3]
SKU:QM-0007461-01
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Product Details
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Description
Nirogacestat (Standard) is the analytical standard of Nirogacestat. This product is intended for research and analytical applications. Nirogacestat (PF-3084014) is a reversible, orally bioavailable, noncompetitive, and selective γ-secretase inhibitor with an IC50 of 6.2 nM. Inhibition of Notch signaling by Nirogacestat while minimizing gastrointestinal toxicity presents a promising approach for research of Notch receptor-dependent cancers[1].
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CAS Number
[1290543-63-3]
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Molecular Formula
C27H41F2N5O
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Molecular Weight
489.64
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Smiles
FC1=C2C(CC[C@H](N[C@@H](CCC)C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)=O)C2)=CC(F)=C1
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Target
Apoptosis; Reference Standards; γ-secretase
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Shipping Conditions
Room temperature
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Nirogacestat (Standard) [CAS 1290543-63-3]
Nirogacestat (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.