Nrf2-IN-4 (hydrobromide)
Nrf2-IN-4 (hydrobromide)
SKU:QM-0012938-01
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Product Details
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Description
Nrf2-IN-4 (Compound PhcY) hydrobromide is a Nrf2 inhibitor. Nrf2-IN-4 hydrobromide induces ferroptosis via NRF2 inhibition. Nrf2-IN-4 hydrobromide disrupts cellular iron homeostasis, facilitates ferritin degradation, and ultimately triggers ferroptosis. Nrf2-IN-4 hydrobromide induces lysosome activation by promoting iron-dependent ROS production and lysosomal acidification. Nrf2-IN-4 hydrobromide demonstrates significant antitumor efficacy. Nrf2-IN-4 hydrobromide can be used for the study of breast cancer[1].
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Molecular Formula
C20H14BrCl2N5S
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Molecular Weight
507.23
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Smiles
ClC1=C(Cl)C=C(C2=CSC(N/N=C(C3=CC=CC=N3)/C4=NC=CC=C4)=N2)C=C1.Br
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Target
Atg8/LC3; Ferroptosis; Keap1-Nrf2; Reactive Oxygen Species (ROS)
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Purity
99.27
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Nrf2-IN-4 (hydrobromide)
Nrf2-IN-4 (hydrobromide) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.