Okadaic acid (ammonium salt) [CAS 175522-42-6]
Okadaic acid (ammonium salt) [CAS 175522-42-6]
SKU:QM-0059069
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Product Details
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Description
Okadaic acid ammonium salt, a marine toxin, is an inhibitor of protein phosphatases (PP) . Okadaic acid ammonium salt has a significantly higher affinity for PP2A (IC50=0.1-0.3 nM), and inhibits PP1 (IC50=15-50 nM), PP3 (IC50=3.7-4 nM), PP4 (IC50=0.1 nM), PP5 (IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid ammonium salt increases of phosphorylation of a number of proteins by inhibiting PP, and acts as a tumor promoter. Okadaic acid ammonium salt induces tau phosphorylation[1][2].
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CAS Number
[175522-42-6]
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Molecular Formula
C44H71NO13
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Molecular Weight
822.03
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Smiles
O[C@H](CC1)[C@@](O[C@@H]1C[C@@](C)(O)C([O-])=O)(C=C2C)O[C@](C2)([H])[C@H](C)/C=C/[C@@H]3O[C@@]4(O[C@]([C@@H](C5=C)O)([H])[C@@](O[C@]5([H])[C@@H](O)C[C@@H]([C@@]6([H])O[C@@]7(CCCCO7)CC[C@H]6C)C)([H])CC4)CC3.[NH4+]
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Target
Phosphatase
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Okadaic acid (ammonium salt) [CAS 175522-42-6]
Okadaic acid (ammonium salt) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.