Okadaic acid (sodium) [CAS 209266-80-8]
Okadaic acid (sodium) [CAS 209266-80-8]
SKU:QM-0080311
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Product Details
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Description
Okadaic acid sodium, a marine toxin, is an inhibitor of protein phosphatases (PP) . Okadaic acid (sodium) has a significantly higher affinity for PP2A (IC50=0.1-0.3 nM), and inhibits PP1 (IC50=15-50 nM), PP3 (IC50=3.7-4 nM), PP4 (IC50=0.1 nM), PP5 (IC50=3.5 nM), but does not inhibit PP2C. Okadaic acid sodium increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid sodium induces tau phosphorylation[1][2].
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CAS Number
[209266-80-8]
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Molecular Formula
C44H67NaO13
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Molecular Weight
826.98
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Smiles
O[C@H](CC[C@@H](C[C@@](C)(O)C(O[Na])=O)O1)[C@@]1(C=C(C)C2)O[C@]2([H])[C@H](C)/C=C/[C@@H]3O[C@@]4(O[C@]([C@@H]5O)([H])[C@@](O[C@@]([C@@H](O)C[C@@H]([C@@]6([H])O[C@@]7(CCCCO7)CC[C@H]6C)C)([H])C5=C)([H])CC4)CC3
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Target
Apoptosis; Phosphatase
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Purity
99.9
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Solubility
10 mM in DMSO
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Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Blue Ice
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Hazard Statement
H301+H311+H331, H315
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Precautions
H301+H311+H331, H315
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Okadaic acid (sodium) [CAS 209266-80-8]
Okadaic acid (sodium) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.