P27 Analogue CP2
P27 Analogue CP2
SKU:QM-0025242
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Product Details
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Description
P27 Analogue CP2 is a macrocyclic peptide inhibitor targeting the SCFSkp2/Cks1 E3 ubiquitin ligase (Kd=32 nM) . p27 Analogue CP2 blocks SCFSkp2/Cks1-mediated ubiquitylation and degradation of p27, restoring p27 levels and inhibiting cell proliferation. p27 Analogue CP2 is promising for research of cancers dependent on Skp2 overexpression such as breast cancer[1].
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Molecular Formula
C51H83N20O20P
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Molecular Weight
1327.3
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Smiles
O=C(NCC(N[C@@H](CO)C(N[C@@H](CCN1C=C(CCNC(NCCC2=CN(CCC[C@@H](C(N[C@H](C(O)=O)CCCCN)=O)NC([C@H]3N(C([C@H]([C@H](OP(O)(O)=O)C)NC([C@@H]4CCC(N)=O)=O)=O)CCC3)=O)N=N2)=O)N=N1)C(N[C@@H](CCC(O)=O)C(N4)=O)=O)=O)=O)[C@@H](N)C
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Target
E1/E2/E3 Enzyme
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Shipping Conditions
Room temperature
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P27 Analogue CP2
P27 Analogue CP2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.