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Pacritinib (hydrochloride) [CAS 1228923-43-0]
Pacritinib (hydrochloride) [CAS 1228923-43-0]
SKU:QM-0073718
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Product Details
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Description
Pacritinib hydrochloride is a potent inhibitor of both wild-type JAK2 (IC50=23 nM) and JAK2V617F mutant (IC50=19 nM) . Pacritinib hydrochloride also inhibits FLT3 (IC50=22 nM) and its mutant FLT3D835Y (IC50=6 nM) . Pacritinib hydrochloride can be used for the research of acute myeloid leukemia (AML) and myelofibrosis (MF) [1][2][3].
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CAS Number
[1228923-43-0]
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Molecular Formula
C28H32N4O3.xClH
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Smiles
[H]Cl.C1(COC/C=C/COCC2=C(OCCN3CCCC3)C=CC4=C2)=CC=CC(C5=N/C(NC=C5)=N\4)=C1.[x]
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Target
FLT3; JAK
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Isoform
JAK1; JAK2; JAK3; Tyk2
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Pacritinib (hydrochloride) [CAS 1228923-43-0]
Pacritinib (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.