Pamidronic acid [CAS 40391-99-9]
Pamidronic acid [CAS 40391-99-9]
SKU:QM-0157393-01
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Product Details
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Description
Pamidronic acid, the second-generation nitrogen-containing bisphosphonate, is an inhibitor of bone loss. Pamidronic acid significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of OPG in cartilage and subchondral bone, and inhibiting the expression of RANKL and MMP-9 in both tissues, as well as TLR-4 in cartilage, thereby alleviating cartilage degeneration. Additionally, Pamidronic acid can inhibit the signaling of Wnt and β-catenin, and is applicable for research on osteoporosis and osteosarcoma[1][2][3][4].
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CAS Number
[40391-99-9]
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Molecular Formula
C3H11NO7P2
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Molecular Weight
235.07
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Smiles
OC(P(O)(O)=O)(P(O)(O)=O)CCN
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Target
RANKL/RANK ; Toll-like Receptor (TLR) ; Wnt; β-catenin
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Concentration
10mM
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Purity
99.05
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Solubility
DMSO : < 1 mg/mL|H2O : 5 mg/mL (ultrasonic; warming; heat to 80°C)
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Storage Conditions
-20°C (Powder, protect from light)
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Shipping Conditions
Blue Ice
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Pamidronic acid [CAS 40391-99-9]
Pamidronic acid is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.