PBT434 (mesylate) [CAS 2387898-69-1]
PBT434 (mesylate) [CAS 2387898-69-1]
SKU:QM-0139927-01
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Product Details
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Description
PBT434 methanesulfonate is a potent, orally active and cross the blood-brain barrier α-synuclein aggregation inhibitor. PBT434 methanesulfonate can be used as a iron chelator and modulates transcellular iron trafficking. PBT434 methanesulfonate inhibits iron-mediated redox activity and iron-mediated aggregation of α-synuclein. PBT434 methanesulfonate prevents the loss of substantia nigra pars compacta neurons (SNpc) . PBT434 methanesulfonate has the potential for the research of Parkinson’s disease (PD) [1][2].
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CAS Number
[2387898-69-1]
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Molecular Formula
C13H17Cl2N3O5S
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Molecular Weight
398.26
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Smiles
O=C1C2=C(N=C(CNCC)N1C)C(O)=C(Cl)C=C2Cl.O=S(O)(C)=O
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Target
α-synuclein
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Isoform
α-synuclein Aggregation
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Concentration
10mM
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Purity
99.92
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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PBT434 (mesylate) [CAS 2387898-69-1]
PBT434 (mesylate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.