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PD-L1/HDAC6-IN-1 [CAS 2834094-36-7]
PD-L1/HDAC6-IN-1 [CAS 2834094-36-7]
SKU:QM-0010344
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Product Details
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Description
PD-L1/HDAC6-IN-1 (Compound HP29) is the inhibitor for PD-L1 and HDAC6 that inhibits the PD-L1/PD-1 interaction and HDAC6 with an IC50 of 26.8 nM and 69 nM. PD-L1/HDAC6-IN-1 enhances the killing ability of Jurkat T cells against HepG2 cells with an IC50 of 3.4 μM. PD-L1/HDAC6-IN-1 exhibits good pharmacokinetics characteristics in rats with a drug exposure of 871.62 ng·h/mL, and exhibits antitumor activity in mouse B16-F10 xenograft models[1].
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CAS Number
[2834094-36-7]
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Molecular Formula
C27H33N3O3
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Molecular Weight
447.57
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Smiles
CC1=C(C=CC=C1C2=CC=CC=C2)C3=NC(OC)=C(C=C3)CNCCCCCCC(NO)=O
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Target
HDAC; PD-1/PD-L1
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Isoform
HDAC1; HDAC6
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Shipping Conditions
Room temperature
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PD-L1/HDAC6-IN-1 [CAS 2834094-36-7]
PD-L1/HDAC6-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.