PD98059 (Standard) [CAS 167869-21-8]
PD98059 (Standard) [CAS 167869-21-8]
SKU:QM-0004598-01
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Product Details
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Description
PD98059 (Standard) is the analytical standard of PD98059. This product is intended for research and analytical applications. PD98059 is a potent and selective MEK inhibitor with an IC50 of 5 µM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC50 of 2-7 µM) and MEK2 (IC50 of 50 µM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC50 of 4 μM) and AHR transformation (IC50 of 1 μM) . PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG) -induced autophagy[1][2][3].
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CAS Number
[167869-21-8]
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Molecular Formula
C16H13NO3
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Molecular Weight
267.28
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Smiles
O=C1C=C(OC2=CC=CC=C21)C3=CC=CC(OC)=C3N
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Target
Aryl Hydrocarbon Receptor; Autophagy; ERK; MEK; Reference Standards
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Purity
99.72
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Storage Conditions
4°C, sealed storage, away from light and moisture
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Shipping Conditions
Blue Ice
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PD98059 (Standard) [CAS 167869-21-8]
PD98059 (Standard) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.