Pevonedistat [CAS 905579-51-3]
Pevonedistat [CAS 905579-51-3]
SKU:QM-0156683-01
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Product Details
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Description
Pevonedistat (MLN4924) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor with an IC50 of 4.7 nM. Pevonedistat induces the deregulation of S-phase DNA synthesis, thereby disrupting protein turnover mediated by cullin-RING ligase, leading to apoptosis of human tumor cells. Pevonedistat suppresses the growth of human tumour xenografts in mice[1].
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CAS Number
[905579-51-3]
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Molecular Formula
C21H25N5O4S
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Molecular Weight
443.52
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Smiles
O=S(OC[C@@H]1C[C@@H](N2C3=NC=NC(N[C@H]4CCC5=C4C=CC=C5)=C3C=C2)C[C@@H]1O)(N)=O
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Target
Apoptosis; NEDD8-activating Enzyme
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Concentration
10mM
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Purity
99.98
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Solubility
DMSO : 62.5 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Pevonedistat [CAS 905579-51-3]
Pevonedistat is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.