Pexidartinib (hydrochloride) [CAS 2040295-03-0]
Pexidartinib (hydrochloride) [CAS 2040295-03-0]
SKU:QM-0154105-01
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Product Details
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Description
Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity[1].
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CAS Number
[2040295-03-0]
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Molecular Formula
C20H16Cl2F3N5
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Molecular Weight
454.28
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Smiles
FC(C1=CC=C(CNC2=NC=C(CC3=CNC4=NC=C(Cl)C=C43)C=C2)C=N1)(F)F.Cl
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Target
Apoptosis; c-Fms; c-Kit
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Purity
99.77
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Solubility
DMSO : 60 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H335
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Precautions
H302, H315, H319, H335
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Pexidartinib (hydrochloride) [CAS 2040295-03-0]
Pexidartinib (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.