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PF-3758309 (hydrochloride) [CAS 1279034-84-2]
PF-3758309 (hydrochloride) [CAS 1279034-84-2]
SKU:QM-0061350
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Product Details
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Description
PF-3758309 (PF-03758309) hydrochloride is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 (Kd= 2.7 nM; Ki=18.7 nM) . PF-3758309 hydrochloride has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation[1][2][3].
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CAS Number
[1279034-84-2]
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Molecular Formula
C25H31ClN8OS
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Molecular Weight
527.08
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Smiles
O=C(N1C(C)(C)C2=NNC(NC3=C4C(C=CS4)=NC(C)=N3)=C2C1)N[C@@H](C5=CC=CC=C5)CN(C)C.[H]Cl
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Target
Apoptosis; PAK
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Isoform
PAK1; PAK2; PAK3; PAK4; PAK5; PAK6
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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PF-3758309 (hydrochloride) [CAS 1279034-84-2]
PF-3758309 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.