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PF-5274857 (hydrochloride) [CAS 1613439-62-5]
PF-5274857 (hydrochloride) [CAS 1613439-62-5]
SKU:QM-0062499
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Product Details
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Description
PF-5274857 hydrochloride is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-5274857 hydrochloride has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway[1].
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CAS Number
[1613439-62-5]
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Molecular Formula
C20H26Cl2N4O3S
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Molecular Weight
473.42
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Smiles
O=C(N1CCN(C2=NC=C(Cl)C(C3=NC=C(C)C=C3C)=C2)CC1)CCS(=O)(C)=O.Cl
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Target
Smo
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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PF-5274857 (hydrochloride) [CAS 1613439-62-5]
PF-5274857 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.