PI3Kδ/HDAC6-IN-1 [CAS 3075011-99-0]
PI3Kδ/HDAC6-IN-1 [CAS 3075011-99-0]
SKU:QM-0011982
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Product Details
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Description
PI3Kδ/HDAC6-IN-1 (Compound 22E) is an orally active and dual inhibitor of PI3Kδ and HDAC6 with IC50 values of 2.4 nM and 6.2 nM, respectively. PI3Kδ/HDAC6-IN-1 exhibits potent antiproliferative effects on non-Hodgkin lymphoma (NHL) cells and possesses in vivo antitumor activity without significant toxicity. PI3Kδ/HDAC6-IN-1 arrests the cell cycle at the G0/G1 phase and induces apoptosis. PI3Kδ/HDAC6-IN-1 blocks the PI3K/AKT/mTOR signaling pathway and increases the acetylation levels of α-tubulin and histone H3[1].
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CAS Number
[3075011-99-0]
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Molecular Formula
C34H38N10O4
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Molecular Weight
650.73
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Smiles
CCC(N1C2=NC(N(C)C(CN3C(CN(CC4=CC=C(/C=C/C(NO)=O)C=C4)CC3)=O)=N5)=C5C(N6CCOCC6)=N2)=NC7=C1C=CC=C7
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Target
Apoptosis; Bcl-2 Family; Caspase; HDAC; Histone Methyltransferase; Microtubule/Tubulin; PI3K; Reactive Oxygen Species (ROS)
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Isoform
HDAC6; PI3Kδ
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Shipping Conditions
Room temperature
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PI3Kδ/HDAC6-IN-1 [CAS 3075011-99-0]
PI3Kδ/HDAC6-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.