PI3K-IN-11 [CAS 884539-95-1]
PI3K-IN-11 [CAS 884539-95-1]
SKU:QM-0118047-01
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Product Details
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Description
PI3K-IN-11 (compound 13) is a PI3K inhibitor, which selectively inhibits PI3Kα, PI3Kβ, PI3K, and PI3Kδ (IC50s=6.4, 13, 8, and 11 nM, respectively) over mTOR (IC50=2.9 μM) . PX-13-17OH is greater than 420-fold selective for PI3K in a panel of 20 lipid and protein kinases. PX-13-17OH inhibits phosphorylation of Akt and S6 kinase (S6K) in PTEN-negative U87MG cells when used at concentrations ranging from 0.03 to 1 μg/mL. It inhibits tumor growth in a U87MG mouse xenograft model when administered at doses ranging from 2.5 to 10 mg/kg.
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CAS Number
[884539-95-1]
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Molecular Formula
C29H42N2O8
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Molecular Weight
546.65
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Smiles
O=C1/C(C([C@]2(C)[C@@H](COC)O1)=C(O)C(C3=C2[C@H](OC(C)=O)C[C@@]4(C)[C@@]3([H])CC[C@@H]4O)=O)=C/N(CCCN(C)C)C
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Target
PI3K
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Shipping Conditions
Room temperature
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PI3K-IN-11 [CAS 884539-95-1]
PI3K-IN-11 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.