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PI3Kα-IN-12 [CAS 2966861-50-5]
PI3Kα-IN-12 [CAS 2966861-50-5]
SKU:QM-0068376
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Product Details
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Description
PI3Kα-IN-12 (compound 13) is a highly selective PI3Kα inhibitor (IC50: 1.2 nM) . PI3Kα-IN-12 inhibits HCT-116 and U87-MG with IC50s values of 0.83 and 1.25 μM, respectively. PI3Kα-IN-12 (40 mg/kg; IP) causes tumor regression in a U87-MG cell line xenograft mouse model[1].
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CAS Number
[2966861-50-5]
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Molecular Formula
C28H36F2N10O5S3
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Molecular Weight
726.84
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Smiles
S=C(N1CCN(C2=NC(N3C(C(F)F)=NC4=C(OC)C=CC=C34)=NC(N5CCOCC5)=N2)CC1)SCC(N6CCN(S(=O)(C)=O)CC6)=O
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Target
PI3K
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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PI3Kα-IN-12 [CAS 2966861-50-5]
PI3Kα-IN-12 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.