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PI3Kα-IN-14 [CAS 3026856-46-9]
PI3Kα-IN-14 [CAS 3026856-46-9]
SKU:QM-0072725
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Product Details
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Description
PI3Kα-IN-14 (compound F8) is a selective PI3Kα inhibitor with an IC50 of 0.14 nM. PI3Kα-IN-14 induces a great decrease in mitochondrial membrane which caused cell cycle arrest at G1 phase and apoptosis in U87-MG cells. PI3Kα-IN-14 shows significant anti-proliferative activities against three tumor-derived cell lines (PC-3: IC50 of 0.28 μM; HCT-116: IC50 of 0.57 μM; and U87-MG: IC50 of 1.37 μM) [1].
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CAS Number
[3026856-46-9]
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Molecular Formula
C28H29ClF2N10O4
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Molecular Weight
643.04
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Smiles
O=C(N1CCN(C2=NC(N3C(C(F)F)=NC4=C(OC)C=CC=C34)=NC(N5CCOCC5)=N2)CC1)NNC(C6=CC=C(Cl)C=C6)=O
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Target
Apoptosis; PI3K
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Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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PI3Kα-IN-14 [CAS 3026856-46-9]
PI3Kα-IN-14 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.