PI3Kδ-IN-16 [CAS 2766437-35-6]
PI3Kδ-IN-16 [CAS 2766437-35-6]
SKU:QM-0151650-01
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Product Details
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Description
PI3Kδ-IN-16 is a potent and selective PI3Kδ inhibitor with an IC50 value of 0.9 nM. PI3Kδ-IN-16 has a strong anti-proliferative effect on SU-DHL-6 cells, causing cell cycle arrest and inducing apoptosis. PI3Kδ-IN-16 tightly bins to PI3Kδ protein with a planar-shaped conformation. The kinase activity of PI3Kδ-IN-16 which is ~378-fold over PI3Kα, 412-fold over PI3Kβ, and 10-fold over PI3Kγ. PI3Kδ-IN-16 can be used for the study of hematologic malignancies[1].
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CAS Number
[2766437-35-6]
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Molecular Formula
C22H26N6O2
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Molecular Weight
406.48
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Smiles
COC1=NC=C(C2=CC3=C(N=CN=C3N[C@@H](C)C(N4CCN(C)CC4)=O)C=C2)C=C1
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Target
Apoptosis; PI3K
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Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
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Purity
99.02
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Solubility
DMSO : 76.92 mg/mL (ultrasonic; adjust pH to 7 with 1 M HCl)
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Storage Conditions
4°C (Powder, protect from light)
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Shipping Conditions
Room Temperature
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PI3Kδ-IN-16 [CAS 2766437-35-6]
PI3Kδ-IN-16 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.