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PI3Kα-IN-22 [CAS 2925030-26-6]
PI3Kα-IN-22 [CAS 2925030-26-6]
SKU:QM-0110194
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Product Details
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Description
PI3Kα-IN-22 (Compound 17) is an orally active, potent and selective inhibitor of PI3KαH1047R, with an IC50 of 1 nM for pAKT T47D AlphaLISA. PI3Kα-IN-22 can induce tumor regressions in the HCC1954 tumor model in mice[1].
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CAS Number
[2925030-26-6]
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Molecular Formula
C24H23F2N5O3
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Molecular Weight
467.47
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Smiles
CC(C=C([C@H](NC1=CC=CC=C1C(O)=O)C)C2=NC(N3CCC(F)(F)CC3)=C4C#N)=CN2C4=O
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Target
PI3K
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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PI3Kα-IN-22 [CAS 2925030-26-6]
PI3Kα-IN-22 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.