PI3Kδ-IN-25
PI3Kδ-IN-25
SKU:QM-0013092
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Product Details
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Description
PI3Kδ-IN-25 is an orally active selective PI3Kδ inhibitor (IC50 = 2.1 nM) . PI3Kδ-IN-25 has IC50s of 272, 285, and 1171 nM for PI3Kα, PI3Kγ, and PI3Kβ, respectively. PI3Kδ-IN-25 inhibits AKT Ser473 phosphorylation, suppresses Treg cell proliferation, and downregulates PD-L1 expression in B16F10 cells. PI3Kδ-IN-25 exhibits anticancer effects in B16F10 melanoma and Lewis lung cancer mouse models by reducing tumor-infiltrating Treg cells and enhancing immune responses. PI3Kδ-IN-25 is potentially useful in the study of melanoma, lung cancer, and other cancers[1].
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Molecular Formula
C26H28N6O4S2
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Molecular Weight
552.67
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Smiles
O=C(N1CC[C@H](NC2=NC=NC3=C2C=C(C4=CC(NS(C5=CC=C(C=C5)C)(=O)=O)=C(N=C4)OC)S3)C1)CC
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Target
Akt; CD3; Interleukin Related; PD-1/PD-L1; PI3K
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Isoform
PI3Kδ
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Shipping Conditions
Room temperature
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PI3Kδ-IN-25
PI3Kδ-IN-25 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.