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PI3Kα-IN-27 [CAS 2098649-83-1]
PI3Kα-IN-27 [CAS 2098649-83-1]
SKU:QM-0015522
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Product Details
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Description
PI3Kα-IN-27 (Compound 50b) is an orally active PI3K-α inhibitor, with an IC50 of 40 nM. PI3Kα-IN-27 effectively inhibits PAK3, p110α, phospho-mTOR and phospho-ERK1/2. PI3Kα-IN-27 induces early Apoptosis. PI3Kα-IN-27 shows anticancer activity against pancreatic cancer, lung cancer, breast cancer[1].
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CAS Number
[2098649-83-1]
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Molecular Formula
C24H30N6O2S
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Molecular Weight
466.6
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Smiles
O=C(NC1CCN(C2=NC(N3CCOCC3)=C4C(C=CS4)=N2)CC1)NC5=CC=C(CC)C=C5
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Target
Apoptosis; mTOR; PAK; PERK; PI3K
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Isoform
PAK3; PI3Kα
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Shipping Conditions
Room temperature
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PI3Kα-IN-27 [CAS 2098649-83-1]
PI3Kα-IN-27 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.