PI3Kα-IN-29
PI3Kα-IN-29
SKU:QM-0016173
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Product Details
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Description
PI3Kα-IN-29 is a potent, orally active and selective PI3Kα with an IC50 of 2.5 nM. PI3Kα-IN-29 exhibits >400-fold selectivity over PI3Kβ/δ/γ/mTOR. PI3Kα-IN-29 selectively degrades the H1047R mutant p110α protein and inhibits PI3Kα kinase activity. PI3Kα-IN-29 suppresses PI3K/AKT/mTOR signaling, induces G1 arrest, and inhibits migration. PI3Kα-IN-29 inhibits tumor growth in a T47 mouse model. PI3Kα-IN-29 can be used for the research of breast cancer[1].
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Molecular Formula
C20H17N5O4
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Molecular Weight
391.38
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Smiles
C[C@H](OC1=CC=C2C3=NC(C4=CC5=C(C=C4)OC(N)=N5)=CN3COC2=C1)C(N)=O
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Target
Akt; Cadherin; CDK; mTOR; PI3K
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Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ
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Shipping Conditions
Room temperature
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PI3Kα-IN-29
PI3Kα-IN-29 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.