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PI3K/mTOR-IN-18 [CAS 1220699-39-7]
PI3K/mTOR-IN-18 [CAS 1220699-39-7]
SKU:QM-0014192
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Product Details
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Description
PI3K/mTOR-IN-18 (Compound 12) is a highly selective dual PI3K/mTOR inhibitor. PI3K/mTOR-IN-18 shows antitumor effects via competitive binding to PI3Kα (Ki=0.130 nM) and mTOR (Ki=0.111 nM) . PI3K/mTOR-IN-18 blocks the PI3K/AKT/mTOR pathway and inhibits tumor cell proliferation (IC50=144 nM) . PI3K/mTOR-IN-18 is promising for research of solid tumors (e.g., breast, NSCLC) [1].
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CAS Number
[1220699-39-7]
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Molecular Formula
C22H23N5O3
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Molecular Weight
405.45
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Smiles
O=C1N([C@H]2CC[C@@H](CC2)O)C3=C(N1C)C=NC4=CC=C(C5=CN=C(OC)C=C5)N=C34
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Target
MTOR; PI3K
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Shipping Conditions
Room temperature
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PI3K/mTOR-IN-18 [CAS 1220699-39-7]
PI3K/mTOR-IN-18 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.