PI3K/mTOR-IN-19
PI3K/mTOR-IN-19
SKU:QM-0015794
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Product Details
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Description
PI3K/mTOR-IN-19 is an orally active, potent, selective PI3K (IC50 = 4.23 nM) and mTOR (IC50 = 2.3 nM) inhibitor. PI3K/mTOR-IN-19 significantly inhibits Eca109 cell viability and induces apoptosis. PI3K/mTOR-IN-19 causes G0/G1 cell cycle arrest, decreased mitochondrial membrane potential, and demonstrates marked telomerase inhibitory activity. PI3K/mTOR-IN-19 modulates the expression of key apoptotic regulators (Bcl-2, Bax, and p53) and downregulates the PI3K/Akt/mTOR signaling pathway. PI3K/mTOR-IN-19 can be used for the study of esophageal cancer[1].
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Molecular Formula
C25H28FN5O3
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Molecular Weight
465.52
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Smiles
O=C(OCCN(CC)CC)C1=CC=C(N2N=NC(C3=NOC(C4=CC=C(F)C=C4)=C3)C2C)C=C1
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Target
Apoptosis; Bcl-2 Family; MDM-2/p53; Mitochondrial Metabolism; mTOR; PI3K; Telomerase
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Isoform
Bax; Bcl-2; mTOR; PI3K
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Shipping Conditions
Room temperature
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PI3K/mTOR-IN-19
PI3K/mTOR-IN-19 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.