PI3KC2γ-IN-1
PI3KC2γ-IN-1
SKU:QM-0015189
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Product Details
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Description
PI3KC2γ-IN-1 (Compound 23) is an orally active and selective PI3KC2γ inhibitor (IC50 = 4 nM) . PI3KC2γ-IN-1 downregulats the Akt2-glycogen synthase (GS) signaling pathway, ultimately inhibiting the conversion of glucose to glycogen and reduces excessive glycogen accumulation in the liver. PI3KC2γ-IN-1 can significantly inhibit insulin-induced PI (3,4) P2 accumulation in both primary hepatocytes and HepG2 liver cancer cells. PI3KC2γ-IN-1 can be used for the study of glycogen storage diseases (GSDs) [1].
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Molecular Formula
C20H14N6O2S
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Molecular Weight
402.43
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Smiles
O=C(NC1=CC=CN=C1)NC2=CC=C(OC(C3=CC=C4N=C(N)SC4=C3)=N5)C5=C2
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Target
PI3K
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Isoform
PI3KC2γ
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Shipping Conditions
Room temperature
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PI3KC2γ-IN-1
PI3KC2γ-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.