Pifusertib (hydrochloride) [CAS 2930090-28-9]
Pifusertib (hydrochloride) [CAS 2930090-28-9]
SKU:QM-0155621-01
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Product Details
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Description
Pifusertib (TAS-117) hydrochloride is a potent, selective, orally active allosteric Akt inhibitor (with IC50s of 4.8, 1.6, and 44 nM for Akt1, 2, and 3, respectively) . Pifusertib hydrochloride triggers anti-myeloma activities and enhances fatal endoplasmic reticulum (ER) stress induced by proteasome inhibition. Pifusertib hydrochloride induces apoptosis and autophagy[1].
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CAS Number
[2930090-28-9]
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Molecular Formula
C26H25ClN4O2
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Molecular Weight
460.96
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Smiles
C[C@@](C1)(O)C[C@]1(N)C2=CC=C(C3=C(N(COC4=CC=NC=C45)C5=N3)C6=CC=CC=C6)C=C2.[H]Cl
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Target
Akt; Apoptosis; Autophagy
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Isoform
Akt1; Akt2; Akt3
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Purity
99.9
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Solubility
DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
4°C (Powder, sealed storage, away from moisture)
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Shipping Conditions
Room Temperature
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Pifusertib (hydrochloride) [CAS 2930090-28-9]
Pifusertib (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.