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PIM-1/HDAC-IN-1 [CAS 2897622-19-2]
PIM-1/HDAC-IN-1 [CAS 2897622-19-2]
SKU:QM-0065172
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Product Details
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Description
PIM-1/HDAC-IN-1 (compound 4d) is a PIM-1 inhibitor, with an IC50 of 343.87 nM. PIM-1/HDAC-IN-1 has strong inhibitory activity and selectivity against HDAC 1 and HDAC 6, with IC50 values of 63.65 and 62.39 nM, respectively. PIM-1/HDAC-IN-1 exhibits apoptosis inducing potential in MCF-7 cell lines. PIM-1/HDAC-IN-1 shows pre-G1 apoptosis and cell cycle arrest at G2/M phase[1].
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CAS Number
[2897622-19-2]
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Molecular Formula
C22H19N3O3
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Molecular Weight
373.4
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Smiles
N#CC1=C(C=C(N=C1OCCCC(NO)=O)C2=CC=CC=C2)C3=CC=CC=C3
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Target
Apoptosis; HDAC; Pim
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Isoform
HDAC; HDAC1; HDAC2; HDAC3; HDAC4; HDAC6; HDAC8; PIM1
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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PIM-1/HDAC-IN-1 [CAS 2897622-19-2]
PIM-1/HDAC-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.