Pittsburgh Compound B [CAS 566169-93-5]
Pittsburgh Compound B [CAS 566169-93-5]
SKU:QM-0005278-01
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Product Details
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Description
Pittsburgh Compound B (PiB) is a PET tracer for Aβ deposition in Alzheimer's disease (AD), with high affinity and specificity. Through click chemistry modification (introducing a PEG3 linker and an alkyne group at the 6-hydroxy position of Pittsburgh Compound B to generate a clickable Pittsburgh Compound B derivative, followed by covalent conjugation with azide-labeled fluorescent dyes or affinity tags via copper-catalyzed azide-alkyne cycloaddition (CuAAC) ), Pittsburgh Compound B and its conjugates can be used for fluorescence imaging, ultrastructural studies, and the enrichment and characterization of Aβ complexes. Pittsburgh Compound B holds great potential in Alzheimer's disease research[1].
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CAS Number
[566169-93-5]
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Molecular Formula
C14H12N2OS
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Molecular Weight
256.33
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Smiles
OC1=CC=C2N=C(SC2=C1)C3=CC=C(C=C3)NC
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Target
Amyloid-β
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Purity
98
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Solubility
DMSO : 50 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
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Shipping Conditions
Room Temperature
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Hazard Statement
H302, H315, H319, H332, H335
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Precautions
H302, H315, H319, H332, H335
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Pittsburgh Compound B [CAS 566169-93-5]
Pittsburgh Compound B is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.