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PKI-179 (hydrochloride) [CAS 1463510-35-1]

PKI-179 (hydrochloride) [CAS 1463510-35-1]

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QM-0136878-01

£363.47 GBP
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Product Details

  • Description

    PKI-179 hydrochloride is a potent and orally active dual PI3K/mTOR inhibitor, with IC50s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α, PI3K-β, PI3K-γ, PI3K-δ and mTOR, respectively. PKI-179 hydrochloride also exhibits activity over E545K and H1047R, with IC50s of 14 nM and 11 nM, respectively. PKI-179 hydrochloride shows anti-tumor activity in vivo[1][2].

  • CAS Number

    [1463510-35-1]

  • Molecular Formula

    C25H29ClN8O3

  • Molecular Weight

    525

  • Smiles

    O=C(NC1=CC=NC=C1)NC2=CC=C(C3=NC(N4C5CCC4COC5)=NC(N6CCOCC6)=N3)C=C2.Cl

  • Target

    MTOR; PI3K

  • Isoform

    MTOR; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

  • Concentration

    10mM

  • Purity

    99.66

  • Solubility

    DMSO : 20 mg/mL (ultrasonic)

  • Storage Conditions

    4°C (Powder, sealed storage, away from moisture)

  • Shipping Conditions

    Room Temperature
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Variant Variant total Quantity Price Variant total
5 mgQM-0136878-01
5 mgQM-0136878-01
£363.47/ea		 £0.00
£363.47/ea £0.00
10 mM - 1 mLQM-0136878-02
10 mM - 1 mLQM-0136878-02
£413.29/ea		 £0.00
£413.29/ea £0.00
10 mgQM-0136878-03
10 mgQM-0136878-03
£551.80/ea		 £0.00
£551.80/ea £0.00
25 mgQM-0136878-04
25 mgQM-0136878-04
£1,053.59/ea		 £0.00
£1,053.59/ea £0.00
50 mgQM-0136878-05
50 mgQM-0136878-05
£1,656.23/ea		 £0.00
£1,656.23/ea £0.00
100 mgQM-0136878-06
100 mgQM-0136878-06
£2,497.01/ea		 £0.00
£2,497.01/ea £0.00
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PKI-179 (hydrochloride) [CAS 1463510-35-1]

PKI-179 (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.