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PLX647 (dihydrochloride) [CAS 1779796-38-1]
PLX647 (dihydrochloride) [CAS 1779796-38-1]
SKU:QM-0063375
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Product Details
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Description
PLX647 dihydrochloride is an orally active, highly specific dual FMS and KIT kinase inhibitor, with IC50s of 28 and 16 nM, reapectively. PLX647 dihydrochloride shows selectivity for FMS and KIT over a panel of 400 kinases at a concentration of 1 μM except FLT3 and KDR (IC50s=91 and 130 nM, respectively) [1].
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CAS Number
[1779796-38-1]
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Molecular Formula
C21H19Cl2F3N4
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Molecular Weight
455.3
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Smiles
FC(F)(F)C1=CC=C(CNC2=CC=C(CC3=CNC4=NC=CC=C43)C=N2)C=C1.Cl.Cl
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Target
C-Fms; c-Kit
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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PLX647 (dihydrochloride) [CAS 1779796-38-1]
PLX647 (dihydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.