Polyporenic acid C [CAS 465-18-9]
Polyporenic acid C [CAS 465-18-9]
SKU:QM-0165174-01
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Product Details
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Description
Polyporenic acid C is a lanostane-type triterpenoid. Polyporenic acid C can be isolated from Poria cocos. Polyporenic acid C causes the cleavage of caspase-8 and caspase-3, as well as the cleavage of PARP. Polyporenic acid C reduces the phosphorylation level of Akt (Ser473), increases the phosphorylation of PTEN and p53 (Ser15), and activates JNK. Polyporenic acid C induces Apoptosis. Polyporenic acid C shows anticancer activity against non-small cell lung cancer[1].
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CAS Number
[465-18-9]
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Molecular Formula
C31H46O4
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Molecular Weight
482.69
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Smiles
C[C@]12[C@@]([C@]([C@H](C(O)=O)CCC(C(C)C)=C)([H])[C@H](O)C1)(CC=C3C2=CC[C@](C4(C)C)([H])[C@@]3(CCC4=O)C)C
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Target
Akt; Apoptosis; Caspase; JNK; MDM-2/p53; PARP; PTEN
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Isoform
Caspase 3; Caspase 8
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Purity
99
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Solubility
DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
4°C (Powder, protect from light)
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Shipping Conditions
Room Temperature
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Polyporenic acid C [CAS 465-18-9]
Polyporenic acid C is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.