Prexasertib (lactate) [CAS 2781996-46-9]
Prexasertib (lactate) [CAS 2781996-46-9]
SKU:QM-0084038
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Product Details
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Description
Prexasertib lactate (LY2606368 lactate) is the lactate form of Prexasertib. Prexasertib lactate is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). Prexasertib lactate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib lactate shows potent anti-tumor activity[1][2].
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CAS Number
[2781996-46-9]
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Molecular Formula
C21H25N7O5
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Molecular Weight
455.47
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Smiles
OC([C@@H](O)C)=O.NCCCOC1=C(C2=CC(NC3=NC=C(C#N)N=C3)=NN2)C(OC)=CC=C1
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Target
Apoptosis; Checkpoint Kinase (Chk) ; DNA/RNA Synthesis
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Isoform
Chk1; Chk2
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Shipping Conditions
Room temperature
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Prexasertib (lactate) [CAS 2781996-46-9]
Prexasertib (lactate) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.