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PRMT5/EGFR-IN-1
PRMT5/EGFR-IN-1
SKU:QM-0130350
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Product Details
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Description
PRMT5/EGFR-IN-1 (Compound 10p) is an orally active dual PRMT5/EGFR inhibitor, with IC50s of 15.47 and 19.31 μM, respectively. PRMT5/EGFR-IN-1 exhibits antiproliferative activity against A549, MCF7, HeLa, and MDA-MB-231 cell lines. PRMT5/EGFR-IN-1 has favorable in vivo PK and PD properties. PRMT5/EGFR-IN-1 can significantly inhibit the growth of MCF7 orthotopic xenograft tumors[1].
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Molecular Formula
C27H22F6N2O2
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Molecular Weight
520.47
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Smiles
COC1=CC(C2NCCC3=C2NC4=CC=CC=C43)=CC=C1OCC5=CC(C(F)(F)F)=CC(C(F)(F)F)=C5
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Target
EGFR; Histone Methyltransferase
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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PRMT5/EGFR-IN-1
PRMT5/EGFR-IN-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.