Propargyl-PEG4-acid [CAS 1415800-32-6]
Propargyl-PEG4-acid [CAS 1415800-32-6]
SKU:QM-0143253-01
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Product Details
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Description
Propargyl-PEG4-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-IAP PROTACs Ibrutinib -based PROTAC 2 and an analogue PROTAC 3. PROTAC 3 causes BTK degradation with a DC50 of 200 nM in THP-1 cells[1]. Propargyl-PEG4-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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CAS Number
[1415800-32-6]
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Molecular Formula
C12H20O6
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Molecular Weight
260.28
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Smiles
C#CCOCCOCCOCCOCCC(O)=O
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Target
PROTAC Linkers
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Isoform
PEG Linkers
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Purity
97
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Solubility
DMSO : 50 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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Hazard Statement
H315, H319, H335
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Precautions
H315, H319, H335
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Propargyl-PEG4-acid [CAS 1415800-32-6]
Propargyl-PEG4-acid is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.