PROTAC BRAF-V600E degrader-1 [CAS 2417296-84-3]
PROTAC BRAF-V600E degrader-1 [CAS 2417296-84-3]
SKU:QM-0146004-01
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Product Details
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Description
PROTAC BRAF-V600E degrader-1 (compound 23) is a potent PROTAC BRAF-V600E degrader whlie no degradation activity against BRAF-WT. PROTAC BRAF-V600E degrader-1 exhibits Kd values of 2.4 nM and 2 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-1 degrades BRAF-V600E via the ubiquitin-proteasome system (UPS) and inhibits the growth of melanoma cells[1]. (In the molecular structure, target protein ligand: BI-882370 , red part; E3 ubiquitin enzyme ligand: Pomalidomide (HY-10984), blue part; PROTAC linker: G007-LK (HY-12438), black part.
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CAS Number
[2417296-84-3]
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Molecular Formula
C48H54F2N10O10S
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Molecular Weight
1001.07
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Smiles
CCCS(=O)(NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C4=NC(N(C5CCN(C(CCOCCOCCOCCNC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O)=O)CC5)C)=CC=C42)=C1F)=O
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Target
PROTACs; Raf
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Isoform
B-Raf
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Purity
98.04
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Solubility
DMSO : 170 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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PROTAC BRAF-V600E degrader-1 [CAS 2417296-84-3]
PROTAC BRAF-V600E degrader-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.