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PROTAC BRAF-V600E degrader-2 [CAS 2417296-82-1]
PROTAC BRAF-V600E degrader-2 [CAS 2417296-82-1]
SKU:QM-0063200
£1,275.93 GBP
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Product Details
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Description
PROTAC BRAF-V600E degrader-2 (compound 12) is a potent BRAF-V600E degrader with Kds of 14.4 nM and 9.5 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-2 selectively degraded the kinase domain of BRAF-V600E but not the wild-type BRAF. PROTAC BRAF-V600E degrader-2 inhibits melanoma cell growth[1].
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CAS Number
[2417296-82-1]
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Molecular Formula
C42H39F2N7O8S
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Molecular Weight
839.86
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Smiles
O=C(NCC1=CC=C(C2=CN=C(NC=C3C(C4=C(F)C=CC(NS(=O)(CCC)=O)=C4F)=O)C3=C2)C=C1)CCCCNC5=CC6=C(C(N(C(CC7)C(NC7=O)=O)C6=O)=O)C=C5
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Target
PROTACs; Raf
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Isoform
B-Raf; Cereblon
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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PROTAC BRAF-V600E degrader-2 [CAS 2417296-82-1]
PROTAC BRAF-V600E degrader-2 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.