PROTAC EGFR degrader 11 [CAS 3034244-71-5]
PROTAC EGFR degrader 11 [CAS 3034244-71-5]
SKU:QM-0153197-01
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Product Details
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Description
PROTAC EGFR degrader 11 (Compound B71) is a PROTAC degrader for epidermal growth factor receptor (EGFR), with DC50 Ki of 36 nM. PROTAC EGFR degrader 11 degrades EGFR, focal adhesion kinase (FAK), and RSK1, inhibits the proliferation of BaF3 wild type and EGFR mutants, with IC50 <100 nM.
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CAS Number
[3034244-71-5]
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Molecular Formula
C49H64ClFN10O7S
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Molecular Weight
991.61
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Smiles
O=C1C(C2=C(F)C=C(N3CCC(OCCN(CC4)CCN4C(CC5)CCN5C(C(CC)=C6)=CC(OC)=C6NC7=NC=C(Cl)C(NC8=CC=C(OC)C=C8N(S(=O)(C)=O)C)=N7)CC3)C=C2)CCC(N1)=O
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Target
EGFR; FAK; PROTACs
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Isoform
Cereblon
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Purity
99.2
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Solubility
DMSO : 100 mg/mL
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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PROTAC EGFR degrader 11 [CAS 3034244-71-5]
PROTAC EGFR degrader 11 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.