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PROTAC EGFR degrader 12 [CAS 2654821-05-1]
PROTAC EGFR degrader 12 [CAS 2654821-05-1]
SKU:QM-0010166
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Product Details
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Description
PROTAC EGFR degrader 12 (example 1) is a PROTAC degrader targeting EGFR that can effectively degrade EGFR mutants, but has little effect on EGFR WT. PROTAC EGFR degrader 12 shows IC50s against EGFRL858R-T790M (NCI-H1975 cells), EGFRL858R (NCI-H3255 cells), and EGFRL858R-T790M-L797S (NCI-H1975+CS cells) of all [1].
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CAS Number
[2654821-05-1]
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Molecular Formula
C48H48F2N10O6S
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Molecular Weight
931.02
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Smiles
OC1(CCN(C2=C(C=C(C=C2)N[C@@H]3C(NC(CC3)=O)=O)F)CC1)CC(N4CC5(C4)CN(C6=CC=C(C7=CC(F)=C(CN(C8=O)C(C9=C%10N(CCC%10)C=N9)C(NC%11=NC=CS%11)=O)C8=C7)C=C6)C5)=O
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Target
EGFR; PROTACs
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Shipping Conditions
Room temperature
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PROTAC EGFR degrader 12 [CAS 2654821-05-1]
PROTAC EGFR degrader 12 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.