PROTAC EGFR degrader 14
PROTAC EGFR degrader 14
SKU:QM-0012981-01
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Product Details
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Description
PROTAC EGFR degrader 14 is a potent and selective EGFR PROTACdegrader with a DC50 of about 2.9 nM and a Dmax of 93.1% for EGFR L858R/T790M/C797S. PROTAC EGFR degrader 14 selectively induces EGFRC797S degradation through a VHL and proteasome-dependent manner and downregulated EGFR-associated transcriptome and exhibits good selectivity over EGFRWT. PROTAC EGFR degrader 14 induces cell cycle arrest and apoptosis and significantly inhibits tumor growth. PROTAC EGFR degrader 14 can be used for the study of nonsmall cell lung cancer (NSCLC) (Pink: Target protein ligand: ; Blue: E3 ligand (HY-125845) ; Black: Linker (HY-W004688) ).
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Molecular Formula
C57H73N11O4S
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Molecular Weight
1008.33
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Smiles
O=C(CCCCCCN1CCN(C2=CC=C(NC3=NC=C4C(N(C(CNC5=CC=CC=C5)=C4)C6CCCC6)=N3)C=C2)CC1)N[C@@H](C(C)(C)C)C(N7[C@H](C(NCC8=CC=C(C9=C(C)N=CS9)C=C8)=O)C[C@@H](O)C7)=O
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Target
Apoptosis; EGFR; PROTACs
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Isoform
Von Hippel-Lindau (VHL)
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Purity
99.26
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Shipping Conditions
Room Temperature
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PROTAC EGFR degrader 14
PROTAC EGFR degrader 14 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.