PROTAC EGFR degrader 15
PROTAC EGFR degrader 15
SKU:QM-0013460
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Product Details
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Description
PROTAC EGFR degrader 15 is a Pomalidomide -based Gefitinib (HY-50895) EGFR PROTAC degrader. PROTAC EGFR degrader 15 triggers EGFR degradation via ubiquitin-proteasome-dependent proteolysis and autophagy-lysosome activation pathways. PROTAC EGFR degrader 15 targets ETFA to enhance ATP production. PROTAC EGFR degrader 15 significantly suppresses tumor growth in a Gefitinib-acquired resistant HCC-827 xenograft model. PROTAC EGFR degrader 15 can be used for the study of non-small cell lung cancer (NSCLC) (Pink: EGFR ligand (HY-W109039) ; Blue: CRBN ligand (HY-10984) ; Black: Linker (HY-W679737) ).
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Molecular Formula
C45H52ClFN8O7
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Molecular Weight
871.4
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Smiles
O=C(N1)CCC(N2C(C(C(NC(CCCCCCCCCN3CCN(CCCOC4=CC(C(NC5=CC(Cl)=C(F)C=C5)=NC=N6)=C6C=C4OC)CC3)=O)=CC=C7)=C7C2=O)=O)C1=O
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Target
ATP Synthase; EGFR; PROTACs
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Isoform
Cereblon
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Purity
97.6
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
-20°C, 3 years (Powder)
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Shipping Conditions
Blue Ice
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PROTAC EGFR degrader 15
PROTAC EGFR degrader 15 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.