PROTAC EGFR degrader 16 [CAS 2654821-07-3]
PROTAC EGFR degrader 16 [CAS 2654821-07-3]
SKU:QM-0015092
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Product Details
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Description
PROTAC EGFR degrader 16 (Compound 98) a selective EGFR PROTAC degrader with DC50 values of EGFR L858R-T970M), NCI-H3225 (EGFR L858R) and NCI-H1976 + CS (EGFR L858R-T970M-L797S). PROTAC EGFR degrader 16 can be used for the study of EGFR-driven cancerssuch as non-small cell lung cancer (Pink: EGFR ligand ; Blue: CRBN ligand (HY-W1128702) ; Black: Linker; EGFR ligand + Linker (HY-178311) ).
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CAS Number
[2654821-07-3]
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Molecular Formula
C48H48F2N10O6S
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Molecular Weight
931.02
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Smiles
O=C(NC1=NC=CS1)C(C2=C(CCC3)N3C=N2)N(CC4=C5C=C(C6=CC=C(N(C7)CC87CN(C(CC9(O)CCN(C%10=CC=C(N[C@H](CC%11)C(NC%11=O)=O)C=C%10F)CC9)=O)C8)C=C6)C=C4F)C5=O
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Target
EGFR; PROTACs
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Isoform
Cereblon; EGFR/ErbB1/HER1
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Shipping Conditions
Room temperature
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PROTAC EGFR degrader 16 [CAS 2654821-07-3]
PROTAC EGFR degrader 16 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.