PROTAC EGFR degrader 4 [CAS 2882845-50-1]
PROTAC EGFR degrader 4 [CAS 2882845-50-1]
SKU:QM-0148912-01
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Product Details
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Description
PROTAC EGFR degrader 4 is a potent PROTAC targeting mutant EGFR.PROTAC EGFR degrader 4 induces EGFRdel19 and EGFRL858R/T790M degradation with DC50s of 0.51 and 126 nM, respectively. PROTAC EGFR degrader 4 significantly inhibits growth of HCC827 and H1975 cell lines with IC50s of 0.83 and 203.1 nM, respectively. Induced EGFR degradation is related to autophagy[1].
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CAS Number
[2882845-50-1]
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Molecular Formula
C55H70N12O4S
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Molecular Weight
995.29
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Smiles
CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCCCN4CCN(CC4)C5=CC=C(C=C5)NC6=NC=C7N=C(N(C7=N6)C8CCCC8)NC9=CC=CC=C9)=O)=O)O)=O
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Target
Autophagy; EGFR; PROTACs
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Purity
99.7
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Solubility
DMSO : 100 mg/mL (ultrasonic)
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Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
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Shipping Conditions
Room Temperature
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PROTAC EGFR degrader 4 [CAS 2882845-50-1]
PROTAC EGFR degrader 4 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.