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PROTAC EGFR degrader 5 [CAS 2409793-36-6]
PROTAC EGFR degrader 5 [CAS 2409793-36-6]
SKU:QM-0066857
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Product Details
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Description
PROTAC EGFR degrader 5 (Compound 10), a PROTAC EGFR degrader, potently degrades EGFRDel19 in HCC827 cells with the DC50 of 34.8 nM. PROTAC EGFR degrader 5 significantly induces the apoptosis of HCC827 cells and arrest the cells in G1 phase[1].
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CAS Number
[2409793-36-6]
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Molecular Formula
C57H72FN13O5S
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Molecular Weight
1070.33
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Smiles
CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCCCCCN4CCN(CC4)C5=CC=C(N=C5)NC6=NC=C7N=C(N=C(C7=C6)N8CCC(CC8)CO)NC9=CC=C(C=C9)F)=O)=O)O)=O
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Target
Apoptosis; EGFR; PROTACs
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Isoform
EGFR/ErbB1/HER1
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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PROTAC EGFR degrader 5 [CAS 2409793-36-6]
PROTAC EGFR degrader 5 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.