PROTAC EGFR degrader 7
PROTAC EGFR degrader 7
SKU:QM-0149471-01
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Product Details
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Description
PROTAC EGFR degrader 7 (compound 13b) is a potent and selective CRBN-recruiting PROTAC EGFRL858R/T790M degrader, with a DC50 of 13.2 nM. PROTAC EGFR degrader 7 inhibits NCI–H1975 cells proliferation, with an IC50 of 46.82 nM. PROTAC EGFR degrader 7 significantly induces apoptosis and G2/M phase arrest in NCI–H1975 cell. PROTAC EGFR degrader 7 shows antitumor activity, and can be used for non-small cell lung cancer (NSCLC) research[1]. PROTAC EGFR degrader 7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Molecular Formula
C46H48N10O6
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Molecular Weight
836.94
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Smiles
C#CCN(CCN(C1=CC(OC)=C(C=C1NC(C=C)=O)NC2=NC(C3=CN(C4=CC=CC=C34)C)=CC=N2)C)CCCC(NC5=C6CN(C(C6=CC=C5)=O)C7CCC(NC7=O)=O)=O
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Target
Apoptosis; EGFR; PROTACs
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Isoform
EGFR/ErbB1/HER1
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Purity
99.99
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Solubility
DMSO : 120 mg/mL (ultrasonic)
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Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Blue Ice
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PROTAC EGFR degrader 7
PROTAC EGFR degrader 7 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.