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PROTAC EGFR degrader 7 (diTFA)

PROTAC EGFR degrader 7 (diTFA)

Size

QM-0149472-01

£991.63 GBP
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Product Details

  • Description

    PROTAC EGFR degrader 7 (compound 13b) is a potent and selective CRBN-recruiting PROTAC EGFRL858R/T790M degrader, with a DC50 of 13[1].2 nM.PROTAC EGFR degrader 7 inhibits NCI-H1975 cells proliferation, with an IC50 of 46[1].82 nM.PROTAC EGFR degrader 7 significantly induces apoptosis and G2/M phase arrest in NCI-H1975 cell.PROTAC EGFR degrader 7 shows antitumor activity, and can be used for non-small cell lung cancer (NSCLC) research[1].

  • Molecular Formula

    C50H50F6N10O10

  • Molecular Weight

    1064.98

  • Smiles

    C#CCN(CCN(C1=CC(OC)=C(C=C1NC(C=C)=O)NC2=NC(C3=CN(C4=CC=CC=C34)C)=CC=N2)C)CCCC(NC5=C6CN(C(C6=CC=C5)=O)C7CCC(NC7=O)=O)=O.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

  • Target

    PROTACs

  • Purity

    99.19

  • Solubility

    DMSO : 100 mg/mL (ultrasonic)

  • Storage Conditions

    -20°C (Powder, sealed storage, away from moisture and light)

  • Shipping Conditions

    Blue Ice
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Variant Variant total Quantity Price Variant total
5 mgQM-0149472-01
5 mgQM-0149472-01
£991.63/ea		 £0.00
£991.63/ea £0.00
10 mgQM-0149472-02
10 mgQM-0149472-02
£1,556.60/ea		 £0.00
£1,556.60/ea £0.00
25 mgQM-0149472-03
25 mgQM-0149472-03
£3,061.99/ea		 £0.00
£3,061.99/ea £0.00
50 mgQM-0149472-04
50 mgQM-0149472-04
£4,882.06/ea		 £0.00
£4,882.06/ea £0.00
100 mgQM-0149472-05
100 mgQM-0149472-05
£7,832.07/ea		 £0.00
£7,832.07/ea £0.00
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PROTAC EGFR degrader 7 (diTFA)

PROTAC EGFR degrader 7 (diTFA) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.