PROTAC EGFR degrader 8 [CAS 2925923-46-0]
PROTAC EGFR degrader 8 [CAS 2925923-46-0]
SKU:QM-0151347-01
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Product Details
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Description
PROTAC EGFR degrader 8 (T-184) is a PROTAC EGFR degrader. PROTAC EGFR degrader 8 degrades EGFR in HCC827 cell with a DC50 of 15.56 nM. PROTAC EGFR degrader 8 inhibits H1975, PC-9, HCC827 cell growth with IC50s of 7.72 nM, 121.9 nM, 14.21 nM. PROTAC EGFR degrader 8 can be used for research of cancer, especially NSCLC[1].
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CAS Number
[2925923-46-0]
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Molecular Formula
C40H46ClN11O5
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Molecular Weight
796.32
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Smiles
O=C(C1=C(NC2=NC(NC3=CC=C(N4CCN(CC4)C(CN5CCN(CC5)C6=CC=C(NC7C(NC(CC7)=O)=O)C=C6)=O)C=C3OC)=NC=C2Cl)C=CC=C1)NC
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Target
EGFR; PROTACs
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Purity
98.9
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Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
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Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
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Shipping Conditions
Blue Ice
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PROTAC EGFR degrader 8 [CAS 2925923-46-0]
PROTAC EGFR degrader 8 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.