PROTAC JAK2 degrader-1
PROTAC JAK2 degrader-1
SKU:QM-0012015
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Product Details
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Description
PROTAC JAK2 degrader-1 (Compound 10i) is a JAK2 PROTAC degrader with a DC50 of 27.35 nM for JAK2 V617F. PROTAC JAK2 degrader-1 promotes the ubiquitination and degradation of JAK2. PROTAC JAK2 degrader-1 inhibits the phosphorylation of JAK2, STAT3 and STAT5. PROTAC JAK2 degrader-1 can be used in the research of myeloproliferative neoplasms (Pink: JAK2 ligand ; Blue: E3 ligase ligand (HY-W087383) ; Black: E3 ligase ligand + linker (HY-174432) ).
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Molecular Formula
C45H51ClFN9O5
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Molecular Weight
852.4
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Smiles
FC1=CC([C@H](OC2=C(N=CC(C3=CN(N=C3)C4CCN(CC4)CC5CN(CC5)CC6CCN(CC6)C7=CC(C(N8C9CCC(NC9=O)=O)=O)=C(C=C7)C8=O)=C2)N)C)=C(C=C1)Cl
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Target
JAK; PROTACs; STAT
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Isoform
Cereblon; JAK2; STAT3; STAT5
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Shipping Conditions
Room temperature
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PROTAC JAK2 degrader-1
PROTAC JAK2 degrader-1 is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.