Prucalopride (hydrochloride) [CAS 179474-80-7]
Prucalopride (hydrochloride) [CAS 179474-80-7]
SKU:QM-0064833
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Product Details
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Description
Prucalopride hydrochloride is an orally active, selective and specific 5-HT4 receptor agonist (high affinity), with pKis of 8.6 and 8.1 for human 5-HT4a/4b receptors, respectively. Prucalopride hydrochloride improves intestinal motility by promoting regeneration of the intestinal nervous system in rats. Prucalopride hydrochloride also shows anticancer activity by blocking of the PI3K/AKT/mTor signaling pathway. Prucalopride hydrochloride can be used in studies of chronic constipation, pseudo-intestinal obstruction and cancer[1][2][3].
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CAS Number
[179474-80-7]
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Molecular Formula
C18H27Cl2N3O3
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Molecular Weight
404.33
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Smiles
ClC1=C(N)C(CCO2)=C2C(C(NC3CCN(CCCOC)CC3)=O)=C1.Cl
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Target
5-HT Receptor
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Isoform
5-HT4 Receptor
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Solubility
10 mM in DMSO
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Shipping Conditions
Room temperature
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Prucalopride (hydrochloride) [CAS 179474-80-7]
Prucalopride (hydrochloride) is a premium-grade research compound supplied by Quantimol for laboratory and scientific applications.